Fyn Kinase: A Potential Therapeutic Target in Acute Kidney Injury

MPS1 kinase as a potential therapeutic target in medulloblastoma

Medulloblastoma is the most common type of malignant brain tumor that affects children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients perform poorly with significant morbidity. Gene expression profiling has revealed that monopolar spindle 1 (MPS1) (TTK1) is highly expressed in medulloblastoma patient samples compared to that noted in normal ce...

The kinase Mirk is a potential therapeutic target in osteosarcoma.

Osteosarcoma is the most common primary malignant bone tumor affecting children and adolescents. The majority of patients are treated by surgery and chemotherapy but have limited alternative therapeutic options. Kinases play an important role in the growth and survival of tumor cells. We aim to identify specific kinases to be vital in the survival of osteosarcoma cells and thus may be a key tar...

A Potential Therapeutic Target in Traumatic Brain Injury

A potential therapeutic target for FLT3-ITD AML: PIM1 kinase.

Patients with acute myeloid leukemia (AML) and a FLT3 internal tandem duplication (ITD) mutation have a poor prognosis, and FLT3 inhibitors are now under clinical investigation. PIM1, a serine/threonine kinase, is up-regulated in FLT3-ITD AML and may be involved in FLT3-mediated leukemogenesis. We employed a PIM1 inhibitor, AR00459339 (Array Biopharma Inc.), to investigate the effect of PIM1 in...

Dyslipidemia after Burn Injury: a Potential Therapeutic Target

Background: Thermal injury can cause many changes in the skin-local responseand in the body in general –systemic response; the metabolic changes represent an important one among systemic response. Dyslipidemia after burn injury is one of the important alterations that resulted from many factors like hypermetabolic state in burn, release of hormones and inflammatory mediators, the aim of this st...